139: Standards for Creating a Paediatric Drug Monograph

Creating a Meta-Model for Semantic Web Service Standards

Annotating web services with semantic information is a tremendous piece of work for persons who are not familiar with the languages and underlying logic. However, a graphical model can assist users to achieve this goal easily. Therefore, we reviewed existing standards and developed a meta-model and UML profile for semantic web services based on the current W3C submissions to enable an automatic...

National Institute on Drug Abuse RESEARCH MONOGRAPH

Clinical monograph for drug formulary review: erectile dysfunction agents.

BACKGROUND Significant advances in the pharmacologic treatment of erectile dysfunction (ERD) have occurred in recent years, most notably the introduction of sildenafil, the first oral selective phosphodiesterase type 5 (PDE5) inhibitor, in 1998. Sildenafil quickly gained acceptance by the medical community and the public because of its broad efficacy for different types of ERD and its ease of u...

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer.

Seven years after the launch of the European Paediatric Medicine Regulation, limited progress in paediatric oncology drug development remains a major concern amongst stakeholders - academics, industry, regulatory authorities, parents, patients and caregivers. Restricted increases in early phase paediatric oncology trials, legal requirements and regulatory pressure to propose early Paediatric In...

Paediatric pharmacy—drug therapy

S afe and effective drug treatment for children requires an understanding of the wide variability and constant changes in pharmacokinetic handling and pharmacodynamic response to drugs that occur during the time from birth to adulthood. An awareness of, and empathy with, the problems and challenges of drug administration throughout childhood is essential if the pharmacist is to be competent and...